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Experts from Brigham Young University in Utah found that addiction is a result of an 'overcorrection' in the brain, a PsychCentral report said. Using two separate drugs to shed weight can be very effective you will find combinations as you're watching FDA now awaiting approval. When dealing with weight-loss and the those who go through it you need to err to the side of caution and allow FDA do its job and demand some investigation be done so your public knows the side effects and perils associated with the medications before we bring them. Keep in mind that drug companies have been in business to make money and that they would say almost anything to keep people on the medications. Researchers discovered that participants taking this drug for the year, lost weight within one month and have kept the weight off throughout the 56 weeks in the study. Contrave can be a combination in the drugs naltrexone and bupropion, which seems to reflect a new trend of weight-loss drugs that are made up of several active ingredient, which can make them more potent and safer. Combo-pilling may be the newest fad or even better the newest into the future under scrutiny and for that reason it is just more publicly known although in the past, comb-pilling to lose weight has been around since the eighties. The biggest reason that using a combination of pills has become popular could be the fact that since right now there are no long term prescription diet pills that have been approved by the FDA aside from orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications even though some of the combinations happen to be rejected or have yet to be approved by the FDA. Seizures can be a side effect with Contrave and must not be taken in people with seizure disorders. The drug could also raise blood pressure and heartbeat, and really should not be used in people who have a history of cardiac event or stroke in the last six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy using the drug. The FDA also warned that Contrave can raise blood pressure level and heartbeat and must not be used in patients with uncontrolled high hypertension, in addition to by anyone with heart-related and cerebrovascular (blood vessel dysfunction impacting the mind) disease. Patients having a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes which has a boxed warning to alert health care professionals and patients for the increased likelihood of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stopping smoking. Suboxone consists of two drugs; buprenorphine and naloxone. The naloxone is irrelevant when the addict uses the medication properly, but when the tablet is dissolved in water and injected the naloxone will cause instant withdrawal. When suboxone can be used correctly, the naloxone is destroyed inside liver soon after uptake in the intestines and contains no therapeutic effect. Buprenorphine may be the active substance; it's absorbed beneath the tongue (and during the entire mouth) but destroyed through the liver if swallowed. There is a formulation of buprenorphine without naloxone called subutex; I purchased this formulation if the patient has apparent problems from naloxone, including headaches after dosing with suboxone. I have also treated addicts who have had gastric bypass, the location where the first section of the intestine is bypassed and also the stomach contents empty in to a more distal part of the small intestine. In such cases the naloxone escapes ?first pass metabolism', the task with normal anatomy in which the drug is taken up with the duodenum and transferred directly to the liver through the portal vein, where it really is quickly and completely destroyed. After gastric bypass naloxone can be adopted by areas of the intestine which are not served through the portal system, causing blood numbers of naloxone sufficient to cause brief, relatively mild withdrawal symptoms.